发明名称 Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
摘要 A composition comprising nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier and methods of making such nanoparticles is described. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol.
申请公布号 AU4866993(A) 申请公布日期 1994.06.16
申请号 AU19930048669 申请日期 1993.09.29
申请人 STERLING WINTHROP INC. 发明人 GEORGE C. NA;NATARAJAN RAJAGOPALAN
分类号 A61K9/00;A61K9/14;A61K9/54;A61K47/34;A61K47/48;A61K49/00;A61K49/04 主分类号 A61K9/00
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