METHOD FOR CONTROLLING O-DESULFATION OF HEPARIN AND COMPOSITIONS PRODUCED THEREBY

摘要

Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated including about 99 % and 75 % desulfated at the 2-O and 3-O positions, respectively.