CREATINE PHOSPHATE, CREATINE PHOSPHATE ANALOGS, AND USES THEREFOR

摘要

The present invention relates to a method of inhibiting tumor growth in an individual by administering creatine phosphate (N-phosphorylcreatine) or an analog thereof. The present invention further relates to compositions useful in the present method, including phosphorylcreatine and analogs of phosphorylcreatine. In one embodiment, phosphorylcyclocreatine is provided as the disodium salt, trihydrate (C5H8N3O5P.Na2.3H2O), which has improved solubility in comparison with the dilithium dihydrate of phosphorylcyclocreatine or cyclocreatine itself. As antitumor agents, N-phosphorylcreatine or an analog thereof can be administered to a mammal (e.g., a human) to inhibit the growth of a tumor.