A new antibiotic cyclic lipopeptide having the formula <IMAGE> wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
申请公布号
US5366880(A)
申请公布日期
1994.11.22
申请号
US19930066282
申请日期
1993.05.21
申请人
MERCK & CO., INC.
发明人
SCHWARTZ, ROBERT E.;MASUREKAR, PRAKASH S.;SESIN, DAVID F.;LIESCH, JERROLD M.;HALLADA, THOMAS C.;HENSENS, OTTO D.