Compositions and methods for treating allergic inflammation through inhibition of NTRK1

摘要

The invention provides methods of treating allergic inflammatory conditions using an anti-neurotrophin tyrosine kinase receptor 1 (NTRK1)-based therapeutic agent, and related compositions and methods.

主权项

1. A method of treating eosinophilic esophagitis (EoE) in a human subject in need thereof, comprising administering to the subject an amount of a tyrosine kinase inhibitor effective to suppress NTRK1 activity in target cells of the human subject, wherein the tyrosine kinase inhibitor is lestaurtinib (CEP-701) or crizotinib.