Protein having cell growth-stimulating and macrophage chemotactic actions, preparative method therefor and use thereof.

摘要

There are described a novel protein derived from Clostridium perfringens FERM BP-4584, method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000 +/- 40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000 +/- 20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.