ENZYMATIC RESOLUTION OF SUBSTITUTED 2-METHYL-PROPIONIC ACID

摘要

Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a (+/-) mixture of a alpha -substituted 2-methyl propionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of (+/-)- ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.