AMINOALKYLCYCLOPROPANE DERIVATIVE

摘要

An optically active compound represented by general formula (1), a racemate thereof, and a pharmaceutically acceptable acid-addition salt thereof, wherein R represents either a C1-C5 (un)saturated linear or branched aliphatic group, or a phenyl group which may be substituted by one to three substituents selected independently from the group consisting of halogen, C1-C4 alkyl, nitro, amino, hydroxy and C1-C4 alkoxy; and the asterisk represents an asymmetric carbon atom. These compounds have a remarkably high NMDA receptor antagonism as compared with the conventional aminomethylcyclopropane derivatives and are useful as a cerebral infarction preventive and an ischemic disease protective.