发明名称 Modified polynucleotides and methods of preparing same
摘要 Compounds having the structure: <IMAGE> wherein B represents 7-deazapurine, or pyrimidine moiety covalently bonded to the C1'-position of the sugar moiety, provided that when B is 7-deazapurine, it is attached at the N9-position of the 7-deazapurine and when B is pyrimidine, it is attached at the N1-position; wherein A represents a moiety consisting of at least three carbon atoms which is capable of forming a detectable complex with a polypeptide when the compound is incorporated into a double-stranded ribonucleic acid, deoxyribonucleic acid duplex, or DNA-RNA hybrid; wherein the dotted line represents a chemical linkage joining B and A, provided that if B is 7-deazapurine, the linkage is attached to the 7-position of the deazapurine, and if B is pyrimidine, the linkage is attached to the 5-position of the pyrimidine; and wherein each of x, y and z represents <IMAGE> or <IMAGE> either directly, or when incorporated into oligo- and polynucleotides, provide probes which are widely useful.
申请公布号 US5449767(A) 申请公布日期 1995.09.12
申请号 US19920886660 申请日期 1992.05.20
申请人 YALE UNIVERSITY 发明人 WARD, DAVID C.;LANGER, PENNINA R.;WALDROP, III, ALEXANDER A.
分类号 C07H19/167;C07H19/173;C07H19/20;C07H21/00;C07H21/02;C12P19/34;C12Q1/18;C12Q1/68;(IPC1-7):C07H21/00 主分类号 C07H19/167
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