发明名称 |
Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss |
摘要 |
A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
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申请公布号 |
US5459135(A) |
申请公布日期 |
1995.10.17 |
申请号 |
US19940200415 |
申请日期 |
1994.02.23 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
GOLUB, LORNE M.;RAMAMURTHY, NANGAVARUM S.;MCNAMARA, THOMAS F.;GREENWALD, ROBERT A. |
分类号 |
A61K31/19;A61K31/215;A61K31/54;A61K31/60;A61K31/65;A61K45/06;A61P1/02;A61P3/00;A61P17/00;A61P19/10;A61P27/02;A61P29/00;A61P43/00;(IPC1-7):A61K31/65;A61K31/40 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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