摘要 |
PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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申请人 |
ABBOTT LABORATORIES |
发明人 |
SUMMERS, JAMES B.;DAVIDSEN, STEVEN K.;HOLMS, JAMES H.;PIREH, DAISY;HEYMAN, H. ROBIN;MARTIN, MICHAEL B.;STEINMAN, DOUGLAS H.;SHEPPARD, GEORGE S.;CARRERA, JR., GEORGE M. |