发明名称 |
Spicamycin derivatives and their use as anticancer agents |
摘要 |
Spicamycin derivative represented by the formula (I) or a salt thereof: <IMAGE> wherein R represents specific diverse substituents, for example, a linear alkadienyl having from 11 to 13 carbon atoms, and R1 and R2 respectively represent H or OH. Examples of specific compounds are 6-[4'-N-(N'-trans,trans 2,4-tridecadienoylglycyl)spicaminyl-amino]purine, and 6-[4'-N-(N'-trans,trans-2,4 dodecadienyoly glycyl) spicaminyl-amino]purine. Comopunds according to this invention are useful as a pharmaceutical for inhibition of a tumor, for example, human colon cancer.
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申请公布号 |
US5461036(A) |
申请公布日期 |
1995.10.24 |
申请号 |
US19920910640 |
申请日期 |
1992.07.08 |
申请人 |
KIRIN BEER KABUSHIKI KAISHA |
发明人 |
OTAKE, NOBORU;KAWAI, HIROYUKI;KAWASAKI, TOMIKO;ODAGAWA, ATSUO;KAMISHOHARA, MASARU;SAKAI, TERUYUKI |
分类号 |
A61K31/70;A61K31/7042;A61K31/7052;A61P35/00;C07H17/02;C07H19/16;C12P19/32;C12R1/465;(IPC1-7):A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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