TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS

摘要

Compounds of formula (I) wherein A) is (a), (b), (c) or (d), X and Y are O, S, SO, SO2, CH2, CO or NR7, R<1> is an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms wherein the 5- or 6-membered ring may be aromatic or non-aromatic. The compounds have been found to have anti-tumour activity. More specifically, the invention concerns pyrrolo (3,2-b) carbazoles, 1H-benzofuro (3,2-f) indoles and 1H-(1) benzothieno (2,3-f) indoles, methods of their preparation, pharmaceutical formulations containing them and their use as anti-tumour agents.