DRUGS DELIVERY SYSTEM FOR THEIR BEING DELIVERED SIMULTANEOUSLY WITH OTHER ENZYME- AND LIGHT-ACTIVATED AGENTS

摘要

FIELD: medicine. SUBSTANCE: soluble biologically active copolymers containing additional chemotherapeutic agent and additional photo-sensibilizers linked by means of enzymatically splittable links. The preparation has both anti-cancer remedy and light-activated medicine attached to the copolymeric carriers. The carriers are selectable from a group incorporating a) copolymeric carrier having anti-cancer agent and light-activated medicine attached to it; b) mixture of copolymeric carriers, one of which carries an anti-cancer agent and the other one carries a light-activated medicine; c) combination of a) and b). Anti-cancer agent is attached to a copolymeric carrier by means of lateral chains which are stable in animal blood circulation system but yield to intracellular hydrolysis through lysosomous enzymes. Light-activated medicine is attachable to a copolymeric carrier by means of splittable lateral chain of the same kind or by means of a non-splittable compound. The preparation being introduced and optional delay for giving time for the copolymer to be absorbed in the cancer tissue being hold, corresponding light sources are to be switched on at the beginning of anti-cancer preparation action period. EFFECT: enhanced effectiveness in destroying cancer cells; low doses of drugs.