Kinetic resolution process

摘要

There is disclosed a method of producing a substantially enantiometrically pure compound from a precursor compound which is present in at least two enantiomeric forms wherein a transition metal catalyst is used to maintain an equilibrium between the enantiomeric forms and an enzyme is used to effect a chemical reaction which converts one of the enantiomeric forms into an enantiomerically pure compound at a rate which is substantially greater than the rate of reaction of the other enantiomeric forms.