发明名称 |
GROUP B STREPTOCOCCUS POLYSACCHARIDE-PROTEIN CONJUGATES, METHODS FOR PRODUCING CONJUGATES, IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES, AND USES THEREOF |
摘要 |
The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy. |
申请公布号 |
CA2928602(A1) |
申请公布日期 |
2016.11.04 |
申请号 |
CA20162928602 |
申请日期 |
2016.05.02 |
申请人 |
PFIZER INC. |
发明人 |
ANDERSON, ANNALIESA SYBIL;BHUPENDER BHALLA, AMARDEEP SINGH;DONALD, ROBERT G.K.;GU, JIANXIN;JANSEN, KATHRIN UTE;KAINTHAN, RAJESH KUMAR;KHANDKE, LAKSHMI;KIM, JIN-HWAN;LIBERATOR, PAUL;PRASAD, AVVARI KRISHNA;RUPPEN, MARK EDWARD;SCULLY, INGRID LEA;SINGH, SUDDHAM;YANG, CINDY XUDONG |
分类号 |
A61K39/385;A61K39/09;A61P31/04;A61P37/04;C07K14/33;C07K14/34 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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