发明名称 |
HUMAN DNASE I VARIANTS |
摘要 |
The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I.
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申请公布号 |
WO9626279(A1) |
申请公布日期 |
1996.08.29 |
申请号 |
WO1996US02421 |
申请日期 |
1996.02.21 |
申请人 |
GENENTECH, INC. |
发明人 |
LAZARUS, ROBERT, A.;SHAK, STEVEN;ULMER, JANA, S. |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61P11/00;A61P43/00;C07K14/47;C12N9/22;C12N15/00;C12N15/55;C12R1/19;C12R1/91;(IPC1-7):C12N15/55 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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