| 摘要 |
<p>Disclosed are imidazonaphthyridine derivatives represented by formula (I) <CHEM> wherein: R<1> represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents <CHEM> wherein R<2> represents hydrogen, lower alkyl, alkenyl, aralkenyl, or -C(R<5>)H-(CH2)n-R<4> (wherein R<4> represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR<6>R<7> wherein R<6> and R<7> independently represents hydrogen or lower alkyl; R<5> represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R<3> represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable salts thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.</p> |
