2,3,4,5-TETRAHYDRO-1,4-BENZOTHIAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF NEUROLOGICAL DISORDERS, SEIZURES, METHOD OF NERVOUS SYSTEM PROTECTION, METHOD OF SYNTHESIS, USING

摘要

FIELD: organic chemistry. SUBSTANCE: invention proposes compounds of the formula (I)where: n = 0, 1 or 2; R,R,Rand Rmean independently H or alkyl (optionally substituted with one or some halogens); Rand Rmean independently H or alkyl or together mean group of the formula =NRwhere R- H, hydroxy, alkyl, phenyl or alkoxy being each alkyl, phenyl and alkoxy were optionally substituted with one or some halogens; Rmeans: (a) - H; (b) - alkyl; (c) - group of the formula -CORwhere R- H, alkyl or phenyl when Rand Rmean H or alkyl (optionally substituted with one or some halogens), or (d) - group of the formula -S(O)Rwhere p = 1 or 2 and R- alkyl or phenyl when Rand Rmean H or alkyl (optionally substituted with one or some halogens) being each alkyl and phenyl were optionally substituted with one or some halogens; R-Rmean independently H, halogen, cyano, nitro, alkyl, alkoxy, alkanoyl, carboxy, alkanoylhydroxy, carbamoyl (optionally substituted with alkyl) or sulfamoyl (optionally substituted with alkyl with 1-4 carbon atoms) being each alkyl, alkoxy, alkanoyl or alkanoylhydroxy is optionally substituted with one or some halogens. Synthesized compounds can be used for treatment of seizures and/or neurological disorders, for example, epilepsy, and/or using as neuroprophylaxis agents (for nervous system protection), for example, for paralysis prophylaxis. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis.