发明名称 |
Method and apparatus for continuously monitoring the concentration of a metabolyte |
摘要 |
The present invention is directed to a method and an apparatus for continuously monitoring the concentration of a metabolite, such as glucose or lactic acid, in biological tissue, in which a perfusion fluid is fed to a microdialysis probe implanted in the subcutaneous tissue and removed therefrom as dialysate after enrichment with the metabolites contained in the lymph. An enzyme is added to the dialysate and/or perfusion fluid, and the concentration of the metabolite in the dialysate is determined under the selective effect of the enzyme at a measuring point which is positioned ex vivo, using an electrochemical sensor. The enzyme is added to the dialysate in the form of a continuous enzyme solution flow upstream of the measuring point and in dependence of the throughput of the microdialysis probe.
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申请公布号 |
US5640954(A) |
申请公布日期 |
1997.06.24 |
申请号 |
US19950435382 |
申请日期 |
1995.05.05 |
申请人 |
PFEIFFER, ERNST;STERNBERG, FABIO |
发明人 |
PFEIFFER, ERNST;STERNBERG, FABIO |
分类号 |
A61B5/00;C12Q1/00;G01N33/487;(IPC1-7):A61B5/00 |
主分类号 |
A61B5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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