发明名称 |
ANGIOSTATIN AND METHOD OF USE FOR INHIBITION OF ANGIOGENESIS. |
摘要 |
<p>The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.</p> |
申请公布号 |
MX9605109(A) |
申请公布日期 |
1997.08.30 |
申请号 |
MX19960005109 |
申请日期 |
1995.04.26 |
申请人 |
THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
MICHAEL S. O'REILLY;M. JUDAH FOLKMAN;KIM LEE SIM;YIHAI CAO |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/43;A61K48/00;A61P9/00;A61P27/02;A61P29/00;A61P35/00;C07H21/04;C07K14/47;C12N5/10;C12N9/68;C12N15/57;C12P21/02;C12P21/08;C12Q1/02;G01N33/15;G01N33/50;G01N33/574;(IPC1-7):C12N15/57;C12N09/68;G01N33/68;C12N05/06;A61K38/48;C07K16/40;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|