发明名称 |
Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
摘要 |
An immunization strategy to provide protection against disease caused by infection with a paramyxoviridae virus, specifically respiratory syncytial virus (RSV) and parainfluenza virus, is described. A priming intranasal administration of a recombinant virus expressing at least one RSV or PIV protein or immunogenic sequence there first is made to the host followed by a booster administration of at least one purified RSV or PIV protein or immunogenic fragment thereof, which may be adjuvanted with alum. This immunization strategy provides a safe and effective means of controlling RSV and PIV infections. The strategy leads to a stronger protective immune response than other strategies and to the induction of a more balanced Th-1/Th-2 type response than previously attained. Novel recombinant poxviruses are provided containing nucleic acid encoding a paramyxovirus protein or immunogenic fragment thereof is a non-essential region of the poxvirus genome, specifically NYVAC-F and ALVAC-F, which produce the F glycoprotein of RSV. |
申请公布号 |
AU3431297(A) |
申请公布日期 |
1998.02.09 |
申请号 |
AU19970034312 |
申请日期 |
1997.07.11 |
申请人 |
CONNAUGHT LABORATORIES LIMITED;VIROGENETICS CORPORATION |
发明人 |
MICHEL H KLEIN;JAMES TARTAGLIA;GEORGE A. CATES;MARY E EWASYSHYN |
分类号 |
A61K39/155;A61K39/275;A61K39/285 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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