| 摘要 |
PCT No. PCT/JP94/01919 Sec. 371 Date May 8, 1996 Sec. 102(e) Date May 8, 1996 PCT Filed Nov. 11, 1994 PCT Pub. No. WO95/13131 PCT Pub. Date May 18, 1995A method for the production of granules by the use of a high speed agitated granulating machine provided with agitating means for rolling and agitating a substance for granulation, spray means for spraying a binding liquid on the substance, disintegrating means for disintegrating particles arising from granulation, and drying means for drying the particles, characterized by effecting the production by causing the means to act on the substance for granulation simultaneously thereby performing the agitating, granulating, disintegrating, and drying operations simultaneously. An apparatus for automatically implementing the method is also disclosed. The method for high speed agitating sterilization according to this invention is capable of producing granules which are extremely homogeneous in contents of components and excellent in flowability and compression moldability. The granules in process of formation do not easily form coarse lumps as by cohesion and the produced granules possess stable quality. The tablets which are produced with the granules obtained by the method of this invention are extremely homogeneous in terms of contents of active components, color tone, etc. and enjoy excellent mechanical strength.
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