SYNTHESIS OF ACETOGENINS

摘要

A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided whi ch proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprisi ng a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.