CYTOPATHIC VIRUSES FOR THERAPY AND PROPHYLAXIS OF NEOPLASIA
摘要
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.
申请公布号
WO9829555(A2)
申请公布日期
1998.07.09
申请号
WO1997US22036
申请日期
1997.12.10
申请人
ONYX PHARMACEUTICALS, INC.
发明人
BISCHOFF, JAMES, R.;NYE, JULIE;LELIA, NG;HORN, SHARON;WILLIAMS, ANGELICA;KIRN, DAVID