A process for manufacturing simvastatin is provided comprising reacting lovastatin with an organic boronic acid to produce a derivative of lovastatin with a hemiboronate group attached to the C-4 carbon of the pyranyl group, methylating the 2-methylbutyryloxy group on the lovastatin derivative to form a 2,2-dimethylbutyryloxy group on the lovastatin derivative and thereafter removing the hemiboronate group to produce simvastatin.
申请公布号
WO9812188(A3)
申请公布日期
1998.07.16
申请号
WO1997CA00655
申请日期
1997.09.05
申请人
BRANTFORD CHEMICALS INC.;MURTHY, K., S.;HORNE, STEPHEN, E.;WEERATUNGA, GAMINI;YOUNG, SHAWN
发明人
MURTHY, K., S.;HORNE, STEPHEN, E.;WEERBATUNGA, GAMINI;YOUNG, SHAWN