发明名称 |
Phosphorus bearing taxanes intermediates |
摘要 |
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
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申请公布号 |
US5808102(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19970916298 |
申请日期 |
1997.08.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
POSS, MICHAEL A.;MONIOT, JEROME L.;TRIFUNOVICH, IVAN D.;KUCERA, DAVID J.;THOTTAHIL, JOHN K.;CHEN, SHU-HUI;WEI, JIANMEI |
分类号 |
C07C233/82;C07C271/22;C07D305/14;C07D407/12;C07D409/12;C07D413/12;(IPC1-7):C07D305/14 |
主分类号 |
C07C233/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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