Penicillaminamide derivatives

摘要

Compounds represented by the general formula (I) wherein n represents 1 or 2; R<1> represents, for example, a C1-C10 alkyl group which may be substituted with a C3-C10 cycloalkyl group or carboxyl group; R<2> represents hydrogen atom, a C1-C10 alkyl group or other; and R<3> represents amino group or amidino group, whose example include trans-4-amino-Ä(S)-N-Ä(S)-2-propoxycarbonylamino-3-isopropylthio-3-met hyl-butanoylÜprolylÜaminomethylcyclohexane The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants.