发明名称 |
Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and usesthereof |
摘要 |
A chimeric glycosylated soluble interleukin-6 receptor (sIL-6R)-interleukin-6 (IL-6) protein (sIL-6R/IL-6) and biologically active analogues are claimed which comprise a fusion protein product between all of the naturally occurring form of sIL-6R and all of the naturally occurring form of IL-6, the sIL-6/IL-6 and analogues being glycosylated in a similar fashion to the glycosylation of naturally occurring sIL-6R and IL-6. Also claimed are: (1) a DNA sequence encoding a chimeric sIL-6R/IL-6 protein and biologically active analogues as above; (2) a DNA vector comprising a DNA sequence encoding a chimeric sIL-6R/IL-6 protein and biologically active analogues as above, the vector being suitable for expression of the chimeric protein in mammalian cells; (3) transformed mammalian cells containing a DNA vector as in (2) which are capable of expressing the sIL-6R/IL-6 chimeric protein sequence carried by the vector and of fully processing the expressed protein and secreting it into the culture medium in which the cells are grown. |
申请公布号 |
AU8127198(A) |
申请公布日期 |
1999.02.08 |
申请号 |
AU19980081271 |
申请日期 |
1998.07.09 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO..LTD. |
发明人 |
MICHEL REVEL;JUDITH CHEBATH;TSVEE LAPIDOT;ORIT KOLLET |
分类号 |
C12N15/09;A61K38/00;A61K38/04;A61P1/16;A61P35/00;C07K14/00;C07K14/54;C07K14/715;C12N5/10;C12N15/62;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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