| 摘要 |
The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. In preferred embodiments, the aqueous solution has between about 0.01% and about 0.8% hydrogen or benzoyl peroxide and between about 0.01% and about 0.4% sodium bicarbonate. In more preferable embodiments of the present invention, the oral lavage (formulation) includes hydrogen peroxide at a concentration of about 0.4% and sodium bicarbonate at a concentration of about 0.2%. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention. This method involves the step of initially providing a premixed preparation comprising water, between about 0.01% and about 0.08% of a peroxide (preferably hydrogen peroxide) and between about 0.01% and about 0.4% bicarbonate (preferably sodium bicarbonate). Oral rinsing with said preparation, particularly multiple daily oral rinsing, is shown to enhance healing of oral lesions and impedes or prevents the development of oral lesions, particularly those oral lesions incident to cancer chemotherapy. SOL may also be used as a dental plaque retardant. The preparation may also serve to maintain the clinical crowns of patients' teeth free of debris during periods of significant myelosuppression, when dental flossing and tooth brushing is not feasible.
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