| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new 3-aminothiophene derivative useful as a synthetic intermediate, etc., of various physiologically active substances such as a medicine, an agrochemical, etc. SOLUTION: This new 3-aminothiophene derivative is a compound of formula I [R1, R2 are H, F, nitro, a lower alkyl, a alkoxy, a lower alkoxycarbonyl or a lower acryl; R3 is a lower alkyl; R4 to R7 are each H or a lower alkyl), e.g. N-(2-hydroxyethyl)-N-methyl-3-aminothiophene. Further, the compound of the formula I is obtained by reacting a 3-halothiophene derivative of formula II (X is a halogen) with an aminoalcohol derivative of formula III in an inert organic solvent such as tetrahydrofuran in the presence of a base such as triethylamine.
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