| 摘要 |
PURPOSE: The echinomycin derivative is provided to improve the dissolving property to a polar solvent, to reduce the cell poisonous function to normal cells. CONSTITUTION: The synthesis in a form of chloride to maximize the polarity of Echinomycin chloride indicated in a structural formula(1) has the steps of: synthesizing the chloride of Echinomycin using Trialkyloxonium tetrafluoroborate or Meerwein salt or using AgClO4 and methyl iodine. In the chemical formula (1), X represents halogen, sulfate, perchlorate which are possible to synthesize sulfonate salt, in the chemical formula (2), n or m represents the number of oxygen from 0 to 2. |
