| 摘要 |
PURPOSE: New colchicine substitutes which can be produced by molecules by fictionalizing the C7 to ketone or fictionalizing the amino group are provide which have a marked antiblastic activity both on the normal cancer cells and on the chemoresistant phenotype. CONSTITUTION: The compound(I) relates to colchicine and thiocolchicine derivatives which can be obtained from these molecules by functionalization of the C7 to ketone or functionalization of the amino group. In formula, R is methoxy or methylthio, R1 is C1-6 straight or chained alkyl or alkenyl, cyclic or heterocyclic molecular, saturated or unsaturated mono or dicarboxyl or acyl residual group of amino acid or beta-di-glucose or 6-deoxygalactose residual group. The compounds have a marked antiblastic activity both on the normal cancer cells and on the chemoresistant phenotype. The compounds can be administered both by injection and orally. Also described is a compound(II).
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