| 摘要 |
<p>A process for the manufacture of d,1- alpha -tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol comprises carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine ÄHN(SO2CF3)2Ü or a metal salt thereof of the formula Met ÄN(SO2CF3)2Ün (I), wherein Met signifies a metal atom selected from the group of boron, magnesium, aluminium, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zink, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold and n signifies the corresponding valency (1, 2, 3, or 4) of the metal atom Met, as the catalyst and in supercritical carbon dioxide or nitrous oxide as the solvent. A further solvent (cosolvent) may be used, which is a lower aliphatic alkanol, ketone or hydrocarbon. The product of the process is the most active member of the vitamin E group.</p> |
