| 摘要 |
Hydrazine derivatives of formula (I) wherein W represents O, S, CO, NR<5>, (CR<3>R<4>)m, or CR<11>; X represents CO, NR<6>, (CH2)n, CR<12> or CHR<13>; Y represents CO, NR<7>, (CH2)p, or CHR<14>; Z represents CO, CS, SO2, or CH2; m stands for 0 or 1; n and p each individually stand for 0, 1, or 2; R<1> represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R<2> represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a group of the formula V-aryl, V-heterocyclyl or -(CH2)q-CH=CR<8>R<9>; R<3>, R<4>, R<5>, R<6> and R<7> each independently represent hydrogen, optionally substituted lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; or R<3> and R<4> together with the carbon atom to which they are attached form a 3- to 8-membered ring; or R<5> and R<6> or R<5> and R<7> together with the nitrogen atoms to which they are attached form a 3- to 8-membered ring; or R<11> and R<12> together with the sp<2> carbon atoms to which they are attached form a fused lower cycloalkenyl, aryl or heteroaryl ring; or R<5> with either R<13> or R<14> together represent lower alkylene in which a CH2 group is optionally replaced by a heteroatom; or either R<6> or R<7> with either R<3> or R<4> together represent lower alkylene in which a CH2 group is optionally replaced by a heteroatom; or R<3> and R<4> together represent lower alkylene in which a CH2 group is optionally replaced by a heteroatom; V represents a spacer group; R<8> and R<9> together represent lower alkylene in which a CH2 group is optionally replaced by a heteroatom; and q stands for 1 or 2; with the provisos that (i) at least one of W, X and Y represents one of the heteroatoms previously indicated for these substituents or CO, (ii) Z represents CO or SO2 or CS when W represents O; (iii) W, X, Y and Z are not all CO and (iv) W, X and Y are not all NR<5>, NR<6> and NR<7>, respectively; and pharmaceutically acceptable salts thereof inhibit the release of tumour necrosis factor alpha (TNF- alpha ) from cells. They can be used as medicaments, especially in the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumours, cachexia, cardiovascular diseases, fever, haemorrhage and sepsis.
|
