Replacement Therapy for Natriuretic Peptide Deficiencies

摘要

Use and methods of use of natriuretic peptide mimetics which bind to and activate natriuretic peptide receptor A in patients with a defect, condition, syndrome, disease or mutation resulting in a functional active ANP99-126 deficiency, for treatment or prophylaxis of cardiovascular disease, including but not limited to hypertension, acute coronary syndrome, cardiomyopathy, cardiac remodeling, left-ventricular hypertrophy, congestive heart failure, heart failure, high blood pressure and coronary artery disease, including use of mimetics with a plurality of amino acid residues and at least one amino acid surrogate of formula I:;;where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification.

主权项

1. A method of treating a patient with a functional atrial natriuretic peptide 99-126 (functional ANP) deficiency, comprising
administering a natriuretic peptide receptor A (NPRA) agonist in an amount sufficient to achieve a concentration of NPRA agonist together with endogenous active ANP99-126, if any, of about 200 pg/mL to about 1,200 pg/mL in the serum or plasma.