| 摘要 |
Provided are a compounds of the formula depicted wherein R1, R2 and R3 are independently hydrogen, optionally substituted alkyl, alkenyl, alkaryl, aryl, cycloalkyl, cycloalkenyl, or heterocyclic ring; or any two of R1, R2 and R3 may be joined together with the carbon atoms to form an optionally substituted cycloalkyl ring; or all three of R1, R2 and R3 may be joined together with the carbon atoms to form an optionally substituted cycloalkyl ring; R4 is selected from -XR5, -XC(W)R6, -XC(W)X'R7 and -C(W)XR8, where W, X and X' are independently selected from O, S and NR9, where X and X' may also be either -S(O)- or -S(O)2-; n is 0 or 1; Y is -S-, -S(O)- or -S(O)2-; Ra, Rb, Rc and Rd are each independently selected from the group consisting of H, sulfate, -C(O)R10 and -P(O)(OR11)2 where R10 and R11 are independently optionally substituted alkyl, alkenyl, alkaryl, aryl, cycloalkyl, cycloalkenyl, or heterocyclic ring; and the remaining symbols are provided in the specification. Such compounds are reported to inhibit binding of toxins and organisms, such as bacteria, virus and fungi, to their receptors.
|
