| 摘要 |
<p>This invention relates to polymorphisms in the human HMG-CoA reductase gene and corresponding novel allelic polypepides encoded thereby. Particular polymorphisms are described in the promoter, exon (15) and introns (2, 5, 15) and (18). The invention also relates to methods and materials for analysing allelic variation in the HMG CoA reductance gene, and to the use of HMG-CoA reductase polymorphism in the diagnosis and treatment of HMG-CoA reductase mediated diseases such as dyslipidemia and other cardiovascular diseases such as myocardial infarction and stroke.</p> |
