| 摘要 |
PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for tachykinin-interstitial diseases, exhibiting excellent antagonism against all of tachykinin receptors and having little toxicity and especially useful as a prophylactic agent, or the like, for asthma, bronchitis, rhinitis, and the like, by including a specific spiropiperidine derivative. SOLUTION: This medicine comprises a compound of formula I [R1 and R2 are each an aryl, a heteroaryl, or the like; A is methylene, carbonyl, or the like; B is single bond, a 1-4C alkylene, or the like; D is O or S; E is a 1-4C alkylene, or the like; formula II is formula III (G is a 5-8C cycloalkene ring, or the like) or formula IV (Ar is an aryl ring, or the like); (n) is 1-3] e.g. 1- 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)-morpholin-2- yl]ethyl}spiro[(2-hydroxy)indane-1,4'-piperidine]} or a compound of formula V (R3 is a lower alkyl), its pharmacologically permissible salt, its ester or the other derivatives.
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