| 摘要 |
PROBLEM TO BE SOLVED: To provide a new screening method for improving ageing and obtain a skin lotion useful for improving ageing by applying the technique. SOLUTION: This method for discriminating an ageing-improving agent is to make a sugar, protein, lipid peroxide and its secondary product coexist, incubate at a temperature close to that of a living body, generate a fluorescent material, further carry out a secondary incubation with making a material to be tested coexist, measure a fluorescence intensity and discriminate a lipofuscin-like material-degrading action of the material to be tested by using fluorescence intensities in the respective cases of presence and absence of the material and the degree of inhibition of the increase of fluorescence intensity by the material as indices. The skin lotion is made to contain the material having the aforesaid lipofuscin-degrading action.
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