IMPROVED LYSOSOMAL ENZYMES AND LYSOSOMAL ENZYME ACTIVATORS
摘要
A polypeptide selected from the group of lysosomal enzymes and lysosomal enzyme activators, comprising at least one introduced glycosylation site as compared to a corresponding parent enzyme or activator. By introducing additional glycosylation sites the resulting glycosylated lysosomal enzyme or activator obtains improved <i>in vivo</i> activity and thereby provides for improved treatment of lysosomal storage diseases.
申请公布号
WO0149830(A3)
申请公布日期
2002.02.07
申请号
WO2000DK00743
申请日期
2000.12.29
申请人
MAXYGEN APS
发明人
OKKELS, JENS, SIGURD;JENSEN, ANNE, DAM;HALKIER, TORBEN;JENSEN, RIKKE, BOLDING;SCHAMBYE, HANS, THALSGAARD