Chiral diphosphines via 2,3 -sigmatropic rearrangement.Application in asymmetric transition metal catalysis

摘要

The present invention refers to Chiral diphosphines selected from a) diphosphines corresponding to the formula wherein R<1> - R<4> are each independently selected from substituted and unsubstituted hydrocarbyl groups, b) diphosphines corresponding to the formula wherein R<1> - R<4> are each independently selected from substituted and unsubstituted hydrocarbyl groups with the proviso that if R<1> and R<2> is phenyl at least one of R<3> and R<4> is different from phenyl c) diphosphines corresponding to the formula wherein R<1> - R<4> are each independently selected from substituted and unsubstituted hydrocarbyl groups and R<5> and R<6> are each independently selected from the group consisting of hydrogen, alkyl and residues of protecting groups, whereby R<6> and R<5> taking together may be an divalent substituent thereby forming a bicyclus, to a method of making same, to a method for preparing a chiral precursor suitable for making the new chiral diphosphines, to transition metal complexes comprising the chiral diphosphines of the present invention, and to the use of either the chiral diphosphines or their transition metal complexes in asymmetric synthesis.