发明名称 |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
摘要 |
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
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申请公布号 |
US6352694(B1) |
申请公布日期 |
2002.03.05 |
申请号 |
US19950403253 |
申请日期 |
1995.03.10 |
申请人 |
GENETICS INSTITUTE, INC.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
JUNE CARL H.;THOMPSON CRAIG B.;NABEL GARY J.;GRAY GARY S.;RENNERT PAUL D. |
分类号 |
A61K35/14;A61K35/28;A61K38/00;A61K38/17;A61K38/46;A61K39/02;A61K39/12;A61K48/00;C07K14/705;C07K16/00;C07K16/28;C12N5/0783;(IPC1-7):A61K35/14;A61K35/26 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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