21910, A MEMBRANE-ASSOCIATED GUANYLATE KINASE AND USES THEREOF

摘要

The invention provides isolated nucleic acid molecules, designated MAGK nucleic acid molecules, which encode novel guanylate kinase related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MAGK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MAGK gene has been introduced or disrupted. The invention still further provides isolated MAGK proteins, antigenic peptides and anti-MAGK antibodies. Treatment and diagnostic methods for cellular growth or proliferation diseases or disorders, e.g, cancer, including, but not limited to colon cancer and lung cancer, utilizing compositions of the invention, are also provided.