| 发明名称 |
Methods of treating retinal disorders with anti-apelin antibodies |
| 摘要 |
This disclosure relates to apelin antigen-binding proteins and methods of using the apelin antigen-binding proteins. The antigen-binding protein may comprise an antibody to apelin and can be used to treat pathological conditions involving angiogenesis. The pathological conditions can comprise cancer or retinopathy and/or retinopathy-related complications. |
| 申请公布号 |
US9493554(B2) |
申请公布日期 |
2016.11.15 |
| 申请号 |
US201514839662 |
申请日期 |
2015.08.28 |
| 申请人 |
AMGEN INC. |
发明人 |
Lu Shu-Chen;Wang Minghan |
| 分类号 |
A61P35/00;A61P27/02;A61K39/395;C07K16/18;G01N33/53;C12P21/02;C12N15/09;C12N15/11;C07H21/02;C07K16/26;G01N33/74;A61K9/00;C07K14/47;C07K14/515;A61K39/00 |
主分类号 |
A61P35/00 |
| 代理机构 |
|
代理人 |
Alexander Lisa E. |
| 主权项 |
1. A method for inhibiting retinal neovascularization in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a monoclonal antibody or fragment thereof, wherein the monoclonal antibody or fragment thereof specifically binds to human apelin at an epitope with the sequence of SEQ ID NO: 32 and inhibits the binding of human apelin to the APJ receptor. |
| 地址 |
Thousand Oaks CA US |
