Glutathione-elevating compositions and uses thereof

摘要

Use of synthetic thiol-containing peptides as highly effective therapeutic and protective agents is described, in clinical and research applications where lifespan and/or viability and functioning of cells is compromised at least partially due to depletion of reduced glutathione, or where viability and functioning of cells can be improved by elevating reduced glutathione levels. More specifically, compositions and methods for treating blood disorders associated with glutathione dysregulation utilizing short thiol-containing peptides selected from the group consisting of Cys-Lys-Met-Cys (SEQ ID NO: 1), Cys-Met-Lys-Cys (SEQ ID NO: 2) and Cys-β-Ala-His-Cys (SEQ ID NO: 3) are described. Further described are compositions and methods for preserving biological samples using the peptides.

主权项

1. A method for treating a blood disorder associated with glutathione dysregulation, the method comprising administering to a subject suffering from a blood disorder associated with glutathione dysregulation a pharmaceutical composition comprising as an active ingredient at least one peptide or a salt thereof having the amino acid sequence selected from the group consisting of:(SEQ ID NO: 1)Cys-Lys-Met-Cys,(SEQ ID NO: 2) Cys-Met-Lys-Cys;and(SEQ ID NO: 3) Cys-β-Ala-His-Cys.