发明名称 Cycloalkane derivatives
摘要 Disclosed herein are therapeutic agents and/or preventive agents for pain or therapeutic agents and/or preventive agents for a sodium channel associated disease. The present invention provides compounds represented by the following formula (I) or pharmacologically acceptable salts thereof:;
申请公布号 US9493448(B2) 申请公布日期 2016.11.15
申请号 US201414502708 申请日期 2014.09.30
申请人 DAIICHI SANKYO COMPANY, LIMITED 发明人 Shinozuka Tsuyoshi;Kobayashi Hiroyuki;Suzuki Sayaka;Tanaka Kyosuke;Kimoto Hiroko;Domon Yuki
分类号 C07D403/12;C07D401/12;C07D285/08;C07D417/12 主分类号 C07D403/12
代理机构 Foley & Lardner LLP 代理人 Foley & Lardner LLP
主权项 1. A method of producing a compound represented by formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 and Ar2 are each independently a heteroaryl group; R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a cyano group; R4 and R5 are each independently a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group; and n is an integer of 1 to 3; wherein the heteroaryl group is optionally substituted with one or two groups independently selected from a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group, a carboxy group, a cyano group, an amino group, a C1-C3 alkylamino group and a di-C1-C3 alkylamino group; and when the heteroaryl group is substituted with two such groups, the two groups are the same as or different from each other, comprising a step of removing a protecting group, P, from the compound of formula (VI)
地址 Tokyo JP