发明名称 |
Cytokine related treatments of disease |
摘要 |
Nucleosides and other compounds to selectively modulate Th1 and Th2 responses relative to each other in the treatment of disease. In one aspect of the invention, administration of a nucleoside or other compound reduces the dosage at which a primary drug is administered. In another aspect of the invention, an abnormality reflected in increased response in one group of cytokines is treated by administering a nucleoside or other compound that increases response in another group of cytokines. In yet another aspect of the invention, a patient is prophylactically treated by administering a nucleoside or other compound that selectively reduces Th1 activity without significantly reducing Th2 activity. In yet another aspect of the invention, a nucleoside or other compound is administered to a patient at a dose that reduces the patient's GTP pool to a degree that selectively reduces one of the Th1 or Th2 responses without significantly reducing the other response. Controlled release dosage forms are particularly contemplated to achieve that result.
|
申请公布号 |
US2002132784(A1) |
申请公布日期 |
2002.09.19 |
申请号 |
US20020136745 |
申请日期 |
2002.04.29 |
申请人 |
TAM ROBERT;WANG GUANGYI;AVERETT DEVRON;RAMASAMY KANDASAMY |
发明人 |
TAM ROBERT;WANG GUANGYI;AVERETT DEVRON;RAMASAMY KANDASAMY |
分类号 |
A61K31/675;(IPC1-7):A61K31/705;A61K31/419 |
主分类号 |
A61K31/675 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|