发明名称 COMPOSITION AND METHOD OF STABILIZATION OF BIOLOGICAL MATERIALS BY DRYING WITHOUT FREEZING
摘要 biology, biochemistry, medicine. SUBSTANCE: invention relates to dry partially amorphous products that comprise an active component and stabilizing mixtures of substances including at least two components. One substance of a stabilizing mixture is taken among a group comprising monosaccharides, disaccharides and zwitterion with a polar residue. The indicated zwitterion means arginine, aspartic acid, citrulline, glutamic acid, ornithine, histidine, lysine. The second substance of a stabilizing mixture is a zwitterion with a nonpolar residue and means acetylphenylalanine ester, alanine, cysteine, glycine, leucine, methionine, tryptophan, valine, sarcosine. Biologically active material means peptides, proteins, glycoproteins, antibodies, viruses, vaccines, cells and other substances. According to a method of preparing amorphous products the solution of biologically active component and indicated stabilizing substances are prepared and then solution is dried without its freezing. Stabilized biological materials show stability in storage at the room temperature and can be used for diagnosis and therapeutic aims. EFFECT: improved method of preparing. 20 cl, 3 dwg, 29 tbl
申请公布号 RU2191003(C2) 申请公布日期 2002.10.20
申请号 RU19980109886 申请日期 1996.10.24
申请人 发明人
分类号 A61K9/14;A61K38/00;A61K38/18;A61K38/19;A61K38/44;A61K47/18;A61K47/26;F26B5/04;(IPC1-7):A61K9/14 主分类号 A61K9/14
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