METHOD OF MAKING BIOLOGICAL TISSUE COMPONENTS

摘要

A method of preparing a biological composite matrix system includes combining tissue microparticles with a curable medium. The tissue microparticles are formed by pulverizing tissue, sorting the pulverized tissue particles, and decellularizing the pulverized tissue particles. The tissue microparticles are then mixed with the curable medium and the resulting composite is cured to form a microparticle-medium composite matrix. The microparticle-medium composite matrix is compressed to increase the strength of the matrix and to increase the density of the microparticles to a predetermined density.

主权项

1. A method of making a composite matrix system having a predetermined density of biological tissue microparticles, comprising:
decellularizing the tissue microparticles to remove cellular and genetic material; mixing the decellularized tissue microparticles into a medium to form a medium-tissue microparticle composite; and plastically compressing the medium-tissue microparticle composite to form the composite matrix having the predetermined density of tissue microparticles.